Connexin 26 distribution in gap junctions between melanocytes in the human vestibular dark cell area
نویسندگان
چکیده
منابع مشابه
Connexin-specific distribution within gap junctions revealed in living cells.
To study the organization of gap junctions in living cells, the connexin isotypes alpha(1)(Cx43), beta(1)(Cx32) and beta(2)(Cx26) were tagged with the autofluorescent tracer green fluorescent protein (GFP) and its cyan (CFP) and yellow (YFP) color variants. The cellular fate of the tagged connexins was followed by high-resolution fluorescence deconvolution microscopy and time-lapse imaging. Com...
متن کاملConformational changes in surface structures of isolated connexin 26 gap junctions.
Gap junction channels mediate communication between adjacent cells. Using atomic force microscopy (AFM), we have imaged conformational changes of the cytoplasmic and extracellular surfaces of native connexin 26 gap junction plaques. The cytoplasmic domains of the gap junction surface, imaged at submolecular resolution, form a hexameric pore protruding from the membrane bilayer. Exhibiting an in...
متن کاملGap junctions and the connexin protein family.
Gap junctions (Gj) form conduits between adjacent cells that are composed of connexin (Cx) protein subunits and allow direct intercellular communication. To date, the connexin gene family comprises 20 members in the mouse and 21 members in the human genome, 19 of which can be grouped as sequence-orthologous pairs. The structure of connexin genes is relatively simple. An untranslated exon 1 is s...
متن کاملClosing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease.
Cells within the vast majority of human tissues communicate directly through clustered arrays of intercellular channels called gap junctions. Gene ablation studies in mouse models have revealed that these intercellular channels are necessary for a variety of organ functions and that some of these genes are essential for survival. Molecular genetics has uncovered that germ line mutations in near...
متن کاملConnexin distribution in the rabbit and rat ciliary body. A case for heterotypic epithelial gap junctions.
PURPOSE To evaluate the distribution of different alpha- and beta-type connexins (Cx) present in the dual layered ciliary body epithelia (CBE) of both rabbit and rat. METHODS Immunocytochemical detection of Cx26, Cx32, Cx43, and Cx50 was performed on frozen sections of rabbit and rat ciliary body using indirect immunofluorescent methods. The identity of the antigens recognized by the monoclon...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2001
ISSN: 0003-276X,1097-0185
DOI: 10.1002/1097-0185(20010201)262:2<137::aid-ar1018>3.0.co;2-2